Processing of G4 DNA by Dna2 Helicase/Nuclease and RPA Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition
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چکیده
Processing of G4 DNA by Dna2 Helicase/Nuclease and RPA Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition Taro Masuda-Sasa, Piotr Polaczek, Xiao P. Peng, Lu Chen and Judith L. Campbell Braun Laboratories, 147-75, California Institute of Technology, Pasadena, CA 91125 Running title: Dna2/RPA/G4 interactions
منابع مشابه
Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition.
The polyguanine-rich DNA sequences commonly found at telomeres and in rDNA arrays have been shown to assemble into structures known as G quadruplexes, or G4 DNA, stabilized by base-stacked G quartets, an arrangement of four hydrogen-bonded guanines. G4 DNA structures are resistant to the many helicases and nucleases that process intermediates arising in the course of DNA replication and repair....
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